1) Hemophilia A is the most common inherited bleeding disorder. Microsatellite is playing important role in the diagnosis of it in the recent years.

2) Objective:To improve the skills of diagnosing severe hemophilia A(HA)and the carriers of the disease by detection of coagulation factor VIII(FVIII)gene inversion.

3) The techniques of prenatal diagnosis for the disease have developed rapidly in resent years. Wereview the update on the gene diagnosis and prenatal diagnosis for Hemophilia A.

4) Objective To find out a simple and specific method for genetic diagnosis of hemophilia A and identification of carriers.

5) Here,(http://sentencedict.com/hemophilia a.html) we review the advance in the research of retroviral vector in the hemophilia A gene therapy.

6) Objective To understand the infection with hepatitis B virus(HBV), Human immunodeficiency virus(HIV) and syphilis in patients with hemophilia A.

7) Thus, More effective DNA markers are needed to be found for linkage analysis of hemophilia A .

8) Objective:To improve the gene diagnosis and carrier detection in for hemophilia A patients and their family members.

9) Herein, we reported a case of the spontaneous intracholecystic hemorrhage in a 35-year-old male with hemophilia A.

10) Our results suggested that if problem of rejection could be resolved, the fetal splenic transplantation would be an effective treatment for hemophilia A.

11) Gene therapy is the best method to approach the complete cure of hemophilia A .

12) Allogenous splenic transplantation ware performed in 10 patients with hemophilia A from 1985 to 1997.

13) To make the carrier detection and prenatal diagnosis in a pedigree with hemophilia A.

14) The development of modern biotechnology, especially of protein purification and gene molecular biology technology, has greatly prompted the prevention, diagnosis and treatment of hemophilia A.